China Manufacturer Supply 99% Afatinib (BIBW 2992) CAS 439081-18-2 for Antitumor

Basic Info

Model NO.	439081-18-2
CAS Number	439081-18-2
Key Words	Afatinib
Type	Pharmaceutical Raw Materials
Usage	for Antitumor
Mf	C24h25clfn5o3
Appearance	White Powder
Alias	Bibw 2992
Manufacturer	Afatinib Manufacturer
Assay	99% Afatinib
Package	1-2 Kg / Aluminum Foil Bag, 25kg/ Drum, as Require
Transport Package	1-2 Kg / Aluminum Foil Bag, 25kg/ Drum, as Require
Specification	99%
Trademark	XRD
Origin	China
HS Code	29349990
Production Capacity	1mt/Year

Product Description

Manufacturer Supply 99% Afatinib (BIBW 2992) CAS 439081-18-2 For Antitumor

Details :

Product name:	Afatinib (BIBW 2992);Gilotrif
Synonyms:	BIBW 2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;Tovok;Tovok, BIBW 2992;BIBW2992 Afatinib;Afatinib (BIBW 2992);ToMtovok;(S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
CAS:	439081-18-2
MF:	C24H25ClFN5O3
MW:	485.944
Purity:	99.5% min
Appearance:	White or Nearly White Crystalline Powder
MOQ:	10G
Specifications:	Pharmaceutical Grade
Deliver time:	About 5 days
Deliver methods:	TNT,EMS,HKEMS,DHL,ect.(door to door)

<sub>Afatinib is pronounced aff-a-tin-ib. It has the brand name Giotrif (jee-oh-triff). It is a type of biological therapy called a tyrosine kinase inhibitor (TKI). It is a treatment for non small cell lung cancer that has spread outside the lung or to other parts of the body.

It has received regulatory approval for use as a treatment for non-small cell lung cancer,although there is emerging evidence to support its use in other cancers such as breast cancer.

3. How afatinib works:

This type of drug works by blocking particular proteins on cancer cells that encourage the cancer to grow. Afatinib blocks proteins called epidermal growth factor receptors (EGFR). Cancers that have these receptors are called EGFR positive.

Between 10 and 15 people out of every 100 with non small cell lung cancer (10 to 15%) have EGFR positive cancer. Doctors check your cancer cells to see if they have the receptors before you have this treatment.

Afatinib may shrink the cancer or stop it growing for a time

4. Uses and fuction:

Afatinib is used to treat a certain type of lung cancer (non-small cell lung cancer) that has spread to other parts of the body. It belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells. It binds to a certain protein (epidermal growth factor receptor-EGFR) in some tumors.

5. Mechanism of action:

Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Afatinib is not only active against EGFR mutations targeted by first generation tyrosine-kinase inhibitors (TKIs) likeerlotinib or gefitinib, but also against mutations such as T790M which are not sensitive to these standard therapies.Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.

COA:</sub>

Item	Requirements	Test Results
Description	Off-white powder	Off-white powder
Identification	HPLC ,NMR	Complies
Residue on Ignition	≤0.10%	0.05%
Loss on Drying	≤0.50%	0.15%
Heavy Metal	≤20ppm	<20ppm
Purity(HPLC)	≥99.0%	99.99%
Conclusion	It complies with EnterpriseStandard

Advantage:

Hongkong XinRunde Chemical is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

 

1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.

2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.

3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to

insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate

4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

Manufacturer Supply 99% Afatinib (BIBW 2992) CAS 439081-18-2 For Antitumor