Memory Killer Cells Can Improve Survival for Melanoma Patients

Jun 18, 2023

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Our skin contains specialised long-lived killer cells that protect against intruders. Researchers at Karolinska Institutet in Sweden and the University of Copenhagen in Denmark have now identified how these cells are formed, and shown that high levels of memory killer cells in cancer tissue correlate with a better survival rate in people with melanoma. The study is published in the journal Immunity.

Certain immune T cells called tissue-resident memory cells are formed locally in the skin and other tissue, and protect against infections that they have encountered before. Some of them express proteins that enable them to kill infected cells. These "memory killer cells" can also contribute to the inflammatory skin disorders vitiligo and psoriasis. Recent research has shown that they are also involved in the body's immune response to various cancers.

The memory killer cells have been shown to respond to immunotherapy, a Nobel Prize-winning cancer therapy involving the tweaking/activation of the immune system. Immunotherapy is normally administered as a complement to other cancer treatments, and there is considerable variation in how patients respond to it.

"We don't know so much about how and why memory killer cells are formed in the skin and what it means for cancer patients," says Professor Yenan Bryceson at the Department of Medicine (Huddinge), Karolinska Institutet. "Finding out how these cells develop enables us to contribute to the development of more efficacious immunotherapy for diseases like melanoma."

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The researchers then went on to study tumour samples from melanoma patients and found that those with a higher rate of survival also had a larger accumulation of epidermal memory killer cells.

"We’ve been able to identify several factors that control the formation of memory killer cells, which play an important part in maintaining a healthy skin," says Liv Eidsmo, dermatologist and professor at the University of Copenhagen in Denmark and researcher at Karolinska Institutet in Sweden. "There's a fine balance between effective protection against tumours and infections in the skin and contribution to inflammatory diseases like vitiligo and psoriasis."

The researchers now aim to harness their findings to optimise the immunotherapy-induced T-cell response to make it even better at eliminating cancer cells in tissues.

Reference: Zitti B, Hoffer E, Zheng W, et al. Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a. Immunity. 2023. doi: 10.1016/j.immuni.2023.05.003

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