Itaconate modulates mitochondria for antiviral IFN-β | Nature Metabolism

Oct 17, 2024

Immunometabolism

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Itaconate is an immunomodulatory metabolite that influences the outcome of infections and inflammatory diseases. New evidence indicates that itaconate-induced inhibition of succinate dehydrogenase regulates type 1 interferon production via the release of mitochondrial RNA, linking TCA cycle modulation to antiviral interferon responses.

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Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany

Thekla Cordes & Karsten Hiller

Research Group Cellular Metabolism in Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany

Thekla Cordes

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Correspondence to Thekla Cordes or Karsten Hiller.

The authors declare no competing interests.

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Cordes, T., Hiller, K. Itaconate modulates mitochondria for antiviral IFN-β. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01146-0

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Published: 15 October 2024

DOI: https://doi.org/10.1038/s42255-024-01146-0

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